Name

Dr Tianfang Wang


Education

2008 PhD, Physical Chemistry, University of Science and Technology of China

2003 Bachelor, Chemical Physics, University of Science and Technology of China


Contact:

+61 754 565 982

twang@usc.edu.au


Previous Positions (For academics/ post docs)

2012 – present,Research fellow, University of the Sunshine Coast.

2012, ARC Research Associate, The University of Adelaide.

2008 – 2011, Post-doctoral fellow, The University of Adelaide.


About

Dr Wang was awarded his PhD in physical chemistry from the University of Science and Technology of China (USTC) in 2008. He then moved to Australia, and undertook postdoctoral research at the University of Adelaide. He joined USC in 2012 to continue his research in the areas of peptide chemistry, mass spectrometry and proteomics. Dr Wang has been exploring the use of negative ion electrospray mass spectrometry for the sequencing of peptides and interesting ion chemistry processes. Currently, his research focus is to identify and characterise pheromones and kairomones from several aquatic animals using mainly proteomic techniques in conjunction with bioinformatics and behavioural assays. Besides, he has extensive research experience in computational chemistry.


Research areas

Discovery proteomics and peptidomics in aquatic animals

Mass spectrometry of peptide chemistry

Protein conformation and function prediction using molecular dynamics simulation

Computational modelling of ion chemistry


Teaching areas

Physical Chemistry

Combustion Chemistry


Professional memberships

Member of Australian New Zealand Society of Mass Spectrometry

Member of Australian Proteomics Society


Awards

Yonghuai Guo Prize, USTC (2007)

Aerospace Information Prize, USTC (2008)


Chapters & Publications

T. T. N. Tran, T. Wang, S. Hack and J. H. Bowie. Fragmentations of [M-H]- anions of peptides containing Ser sulfate. A joint experimental and theoretical study. Rapid Commun. Mass Spectrom., 2013, 27, 2287-2296.

T. T. N. Tran, T. Wang, S. Hack and J. H. Bowie. Fragmentations of [M-H]- anions of peptides containing tyrosine sulfate. Does the sulfate group rearrange? A joint experimental and theoretical study. Rapid Commun. Mass Spectrom., 2013, 27, 1135-1142.

A. N. Calabrese, T. Wang, J. H. Bowie and T. L. Pukala. Negative ion fragmentations of disulfide-containing cross-linking reagents are competitive with aspartic acid side-chain induced cleavages. Rapid Commun. Mass Spectrom., 2012, 1, 238-248.

T. Wang, T. T. N. Tran, A. N. Calabrese and J. H. Bowie. Backbone fragmentations of [M-H]- anions from peptides. Reinvestigation of the mechanism of the beta prime cleavage. Rapid Commun. Mass Spectrom., 2012, 26, 1832-1840.

A. N. Calabrese, N. J. Good, T. Wang, J. He, J. H. Bowie and T. L. Pukala. A negative ion mass spectrometry approach to identify cross-linked peptides utilizing characteristic disulfide fragmentations. J. Am. Soc. Mass Spectrom., 2012, 23, 1364-1375.

T. Wang and J. H. Bowie. Does hydrogen tunnelling influence the isomerisation of some small radicals of interstellar importance? A theoretical investigation. Org. Biomol. Chem., 2012, 10, 3219-3228.

T. Wang and J. H. Bowie. Can cytosine, thymine and uracil be formed in interstellar regions? A theoretical study. Org. Biomol. Chem., 2012, 10, 652-662.

T. T. N. Tran, T. Wang, S. Hack and J. H. Bowie. Can collision induced negative ion fragmentations of [M-H]- anions be used to identify phosphorylation sites in peptides? Rapid Commun. Mass Spectrom., 2011, 25, 3537-3548.

T. Wang and J. H. Bowie. Studies of cyclisation reactions of linear cumulenes and heterocumulenes using the neutralization-reionization procedure and/or ab initio calculations. Mass Spectrom. Review, 2011, 30, 1225-1241.

T. Wang, T. T. N. Tran, D. Scanlon, H. J. Andreazza, A. D. Abell and J. H. Bowie. Diagnostic di- and triphosphate cyclisation in the negative ion electrospray mass spectra of phosphoSer peptides. Rapid Commun. Mass Spectrom., 2011, 25, 2649-2656.

T. T. N. Tran, T. Wang, S. Hack and J. H. Bowie. Diagnostic cyclisation reactions which follow phosphate transfer to carboxylate anion centres for energized (M-H)- anions of pTyr containing peptides. Rapid Commun. Mass Spectrom., 2011, 25, 2489-2499.

S. T. Ellis-Steinborner, D. Scanlon, I. F. Musgrave, T. T. N. Tran, S. Hack, T. Wang, A. D. Abell1, M. J. Tyler and J. H. Bowie. An unusual kynurenine-containing opioid tetrapeptide from the skin gland secretion of the Australian red tree frog Litoria rubella. Sequence determination by electrospray mass spectrometry. Rapid Commun. Mass Spectrom., 2011, 25, 1735-1740.

T. Wang, H. J. Andreazza, T. L. Pukala, P. J. Sherman, A. N. Calabrese and J. H. Bowie. Histidine-containing host-defence skin peptides of anurans bind Cu2+. An electrospray ionisation mass spectrometry and computational modelling study. Rapid Commun. Mass Spectrom., 2011, 25, 1209-1221.

D. J. Knowles, T. Wang and J. H. Bowie. Radical formation of amino acid precursors in interstellar regions? Ser, Cys and Asp. Org. Biomol. Chem., 2010, 8, 4934-4939.

T. Wang and J. H. Bowie. Radical routes to interstellar glycolaldehyde. The possibility of stereoselectivity in gas-phase polymerization reactions involving CH2O and .CH2OH. Org. Biomol. Chem., 2010, 8, 4757-4766.

T. Wang, N. M. M. Nibbering and J. H. Bowie. The gas phase smiles rearrangement of anions PhO(CH2)nO- (n = 2–4). A joint theoretical and experimental approach. Org. Biomol. Chem., 2010, 8, 4080-4084.

T. Wang, P. C. H. Eichinger, S. Dua and J. H. Bowie. Are the anions MeO(CO)n-(n=1 and 2) methoxide anion donors in the gas phase? A theoretical investigation. Rapid Commun. Mass Spectrom. 2010, 24, 1895-1901.

T. Wang, S. Dua and J. H. Bowie. Formation of neutral NCCCCCN by charge-stripping of (NCCCCCN)-. in the gas phase. How does energized NCCCCCN lose C? A joint experimental and theoretical study. J. Phys. Chem. A, 2010, 104, 949-955.

D.-L. Han, T. Wang, Z.-K. Lin, Y.-H. Hu, F.-Q.Zhao, J.-H. Yi and S.-F. Li. Promoting effects of polyacrylamide on ignition and combustion of Al/H2O based fuels: experimental studies of polyacrylamide aqueous solution flash pyrolysis. J Anal. Appl. Pyrolysis, 2010, 87, 56-64.

T. Wang and J. H. Bowie. Gas-phase intramolecular anion rearrangements of some trimethylsilyl-containing systems revisited. A theoretical approach. Rapid Commun. Mass Spectrom., 2010, 24, 57-62.

M. J. Maclean, S. Walker, T. Wang, P. C. H. Eichinger and J. H. Bowie. Diagnostic fragmentations of adducts formed between the pheyl, benzyl, tolyl and β-phenylethyl anions with carbon disulfide in the gas phase. A joint experimental and theoretical study. Org. Biomol. Chem., 2010, 8, 371-377.

T. Wang, M. A. Buntine and J. H. Bowie. A theoretical study of the isomers of isoelectronic C4, (C3B)- and (C3N)+. Rearrangements through cyclic isomers. J. Phys. Chem. A, 2009, 113, 12952-12960.

T. Wang and J. H. Bowie. A theoretical study of the rearrangement processes of energized CCCB and CCCAl. Phys. Chem. Chem. Phys., 2009, 11, 7553-7561.

H. J. Andreazza, T. Wang, C. J. Bagley, P. Hoffmann and J. H. Bowie. Negative ion fragmentations of deprotonated peptides. The unusual case of isoAsp: a joint experimental and theoretical study. Rapid Commun. Mass Spectrom., 2009, 23, 1993-2002.

T. Wang, Y.-H.Hu, S.-F. Li and D.-L. Han. Effects of 2H-Heptafluoropropane on the liquid and tar products of PMMA flash pyrolysis, J Anal. Appl. Pyrolysis, 2009, 1, 39-46.24.

Z.-K.Lin, T. Wang, D.-L. Han, X. Han, S.-F. Li, Y.-Y. Li and Z.-Y. Tian. Combustion mechanism of fuel-rich MMA/O2/Ar studied by tunable synchrotron VUV photoionization mass spectrometry, Rapid Commun. Mass Spectrom., 2009, 1, 85-92.

H. J. Andreazza, T. Wang, D. Bilusich, P. Hoffmann and J. H. Bowie. Negative ion fragmentations of deprotonated peptides containing post-translational modifications: diphosphorylated peptides containing Ser, Thr and Tyr. A phosphate/phosphate cyclisation reaction. A joint experimental and theoretical study. Rapid Commun. Mass Spectrom., 2009, 23, 1825-1833.

T. Wang, H. J. Andreazza, D. Bilusich and J. H. Bowie. Negative ion fragmentations of deprotonated peptides containing post-translational modifications. An unusual cyclisation/rearrangement involving phosphotyrosine: a joint experimental and theoretical study. Rapid Commun. Mass Spectrom., 2009, 23, 1669-1677.

M. J. Maclean, P. C. H. Eichinger, T. Wang, M. Fitzgerald and J. H. Bowie. A theoretical study of the cyclisation processes of energised CCCSi and CCCP. J. Phys. Chem. A, 2008, 112, 12714-12720.

T. Wang, S.-F. Li, Z.-K. Lin, D.-L. Han and X. Han, Experimental study of laminar lean premixed methylmethacrylate/oxygen/argon flame at low pressure, J. Phys. Chem. A., 2008, 112, 1219-1227.

Z.-K. Lin, T. Wang, X. Han, D.-L. Han and S.-F. Li, Comparative studies on low-temperature pyrolysis products of pure PEG and PEG/nano-Co3O4 by Py-GC/MS, J. Anal. Appl. Pyroly., 2008, 81, 121-126.3.

T. Wang, S.-F. Li, B. Yang, C.-Q. Huang and Y.-Y. Li, Thermal decomposition of glycidyl azide polymer studied by synchrotron photoionization mass spectrometry, J. Phys. Chem. B., 2007, 111, 2449-2455.

J. Zhi, S.-F. Li, K. Li, T. Wang, G.-C. Zhang, H. Wang and X.-M. Ma. Laser ignition and combustion properties of composite propellant containing nanometal powders, AIAA J., 2006, 44, 1463-1467.

IMBC2013, T. Wang, M. Hammond, M. J. Stewart, B. M. Degnan and S. F. Cummins. Composition and antimicrobial activity of partial peptidome of the Great Barrier Reef sponge Amphimedon queenslandica.

2013-the 24th ANZSMS conference, Melbourne, Australia. T. T. N. Tran, T. Wang, S. Hack and J. H. Bowie. Fragmentations of [M-H]- anions of peptides containing Tyr sulfate. Does the sulfate group rearrange? A joint experimental and theoretical study.

2011-the 23rd ANZSMS conference, Fremantle, Australia. T. T. N. Tran, T. Wang and J. H. Bowie, Negative ion chemistry of (M-H)- ions of peptides containing phosphoSer, Thr and Tyr. Characteristic fragmentations and unusual rearrangement reactions.

S.-F. Li, Z.-K. Lin and T. Wang, Effects of aluminum size on the combustion characteristics of high energy propellant with higher burning Rate, The 42nd AIAA/ASME/SAE/ASEE Joint Propulsion Conference Proceedings, 2006.

X. Han, T. Wang and S.-F. Li, Effects of fullerene on thermal decomposition characteristics of ammonium perchlorate, The 41st AIAA/ASME/SAE/ASEE Joint Propulsion Conference Proceedings, 2005.


Research grants

Project Title: Harnessing molluscan neurohormones to develop new molluscicides

Grant Scheme: Australian Government, Grains Research and Development Corporation, $145 k


Project Title: Development of a peptide based interleukin 10 inhibitor for better immunotherapy

Grant Scheme: Sunshine Coast Council, $10 k


Project Title: Breaking the snail trail – USC’s contribution to the international snail genome project

Grant Scheme: University of the Sunshine Coast, $19.8 k


Project Title: What’s hot in wasp snot? Identifying bioactivity of phytotoxic mucus

Grant Scheme: University of the Sunshine Coast, $7 k


Project Title: Increasing the efficacy of HPV therapeutic vaccines by IL-10 signalling blockade

Grant Scheme: National Natural Science Foundation of China, $140 k


Project Title: Discovery of novel bioactive and bioengineering proteins and peptides from marine sponge Amphimedon queenslandica

Grant Scheme: University of the Sunshine Coast, $20 k